Effects of nicotine on cytochrome P450 2A6 and 2E1 activities
β Scribed by Janne Hukkanen; Peyton Jacob III; Margaret Peng; Delia Dempsey; Neal L. Benowitz
- Book ID
- 108642434
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 600 KB
- Volume
- 69
- Category
- Article
- ISSN
- 0306-5251
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## Abstract Cytochrome P450 (CYP) 2A6 and __CYP2E1__ are enzymes with a high ability to activate a nitrosamine, 4β(methylnitrosamino)β1β(3βpyridyl)β1βbutanone (NNK), to its potent and ultimate carcinogens. The polymorphic __CYP2A6__ and __CYP2E1__ have been implicated in increased susceptibility to
The interaction of antiparasitic drugs with the polymorphic cytochrome P450 2D6 was studied in human liver microsomes. Of ten different drugs tested, three quinolines, oxamniquine, primaquine and chloroquine inhibited microsomal CYP2D6-catalysed formation of l'hydroxybufuralol at concentrations tha