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Effect of pre-treatment with dichloroacetic or trichloroacetic acid in drinking water on the pharmacokinetics of a subsequent challenge dose in B6C3F1 mice

✍ Scribed by Alberto Gonzalez-Leon; James L. Merdink; Richard J. Bull; Irvin R. Schultz

Book ID
114009812
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
148 KB
Volume
123
Category
Article
ISSN
0009-2797

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The effect of dichloroacetic acid and tr
The effect of dichloroacetic acid and trichloroacetic acid on DNA methylation and cell proliferation in B6C3F1 mice
✍ Rongrong Ge; Siming Yang; Paula M. Kramer; Lianhui Tao; Michael A. Pereira πŸ“‚ Article πŸ“… 2001 πŸ› John Wiley and Sons 🌐 English βš– 181 KB

## Abstract The chlorine disinfection by‐products, dichloroacetic acid (DCA) and trichloroacetic acid (TCA), are carcinogenic in mouse liver. We have previously reported that DCA and TCA induced DNA hypomethylation in mouse liver. In the present study, we determined the temporal association for DNA