Effect of polysorbate 80 and oleic acid on drug absorption from the rat intestine
✍ Scribed by Gerhard Levy; Aino Perälä
- Publisher
- John Wiley and Sons
- Year
- 1970
- Tongue
- English
- Weight
- 210 KB
- Volume
- 59
- Category
- Article
- ISSN
- 0022-3549
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📜 SIMILAR VOLUMES
Low concentrations of a nonionic surfactant (poly- sorbate 80) in the bathing solution increase significantly the absorption and exsorption rate constants of 4-aminoantipyrine in goldfish. This effect is evident in absorption and exsorption studies involving chemical assays as well as in experiments
Modern drug discovery chemical libraries contain a large number of molecular entities exhibiting low aqueous solubility, often necessitating the inclusion of solubilizing agents in preclinical models of absorption or metabolism. The objective of the present study was to investigate the effects of se