𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Effect of Complex formation on drug absorption XIV: Effect of N,N-di-n-propylpropionamide on intestinal absorption of certain nonsteroid drugs in the rat

✍ Scribed by William L. Hayton; Gerhard Levy; Carl-Gunnar Regårdh

Publisher
John Wiley and Sons
Year
1972
Tongue
English
Weight
193 KB
Volume
61
Category
Article
ISSN
0022-3549

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Absorption barriers in the rat intestina
Absorption barriers in the rat intestinal mucosa. 3: Effects of polyethoxylated solubilizing agents on drug permeation and metabolism
✍ Daniel R. Mudra; Ronald T. Borchardt 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 207 KB 👁 1 views

Modern drug discovery chemical libraries contain a large number of molecular entities exhibiting low aqueous solubility, often necessitating the inclusion of solubilizing agents in preclinical models of absorption or metabolism. The objective of the present study was to investigate the effects of se

N-(3,4-dimethoxyphenethyl)-4-(6,7-dimeth
N-(3,4-dimethoxyphenethyl)-4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2[1H]-yl)-6,7-dimethoxyquinazolin-2-amine (CP-100,356) as a “chemical knock-out equivalent” to assess the impact of efflux transporters on oral drug absorption in the rat
✍ Amit S. Kalgutkar; Kosea S. Frederick; Jonathan Chupka; Bo Feng; Sarah Kempshall 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 193 KB

The utility of the diaminoquinazoline derivative CP-100,356 as an in vivo probe to selectively assess MDR1/BCRP-mediated drug efflux was examined in the rat. CP-100,356 was devoid of inhibition (IC 50 >50 mM) against major human P450 enzymes including P4503A4. In human MDR1-transfected MDCKII cells,