Effect of polyriboinosinic acid on RNA chain initiation
โ Scribed by D. Hunt; H.G. Klemperer
- Book ID
- 115743957
- Publisher
- Elsevier Science
- Year
- 1970
- Weight
- 169 KB
- Volume
- 204
- Category
- Article
- ISSN
- 0005-2787
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๐ SIMILAR VOLUMES
## Abstract Within a few hours following a single intraperitoneal injection of polyriboinosinicโpolyribocytidylic acid (poly I:poly C) into C3H/He mice, numbers of boneโmarrow and spleenโcolonyโforming cells are significantly decreased. The doseโresponse curve obtained shows an exponential decrease
Polyriboinosinic acid (poly I) inhibits initiation of transcription by binary complexes formed between Adenovirus 2 DNA and E. coli RNA polymerase holoenzyme. In the presence of poly I, just as in the presence of rifampicin, initiation of transcription exhibits a sigmoidal dependence on the temperat