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Effect of polyriboinosinic acid on RNA chain initiation

โœ Scribed by D. Hunt; H.G. Klemperer


Book ID
115743957
Publisher
Elsevier Science
Year
1970
Weight
169 KB
Volume
204
Category
Article
ISSN
0005-2787

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## Abstract Within a few hours following a single intraperitoneal injection of polyriboinosinicโ€polyribocytidylic acid (poly I:poly C) into C3H/He mice, numbers of boneโ€marrow and spleenโ€colonyโ€forming cells are significantly decreased. The doseโ€response curve obtained shows an exponential decrease

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Polyriboinosinic acid (poly I) inhibits initiation of transcription by binary complexes formed between Adenovirus 2 DNA and E. coli RNA polymerase holoenzyme. In the presence of poly I, just as in the presence of rifampicin, initiation of transcription exhibits a sigmoidal dependence on the temperat