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Effect of poly(ADP-ribose)polymerase inhibitors on the frequency of sister-chromatid exchanges in Bloom syndrome cells

✍ Scribed by Yukimasa Shiraishi; Yuko Tanaka; Mieko Kato; Masanao Miwa; Takashi Sugimura

Book ID
113254369
Publisher
Elsevier Science
Year
1983
Weight
325 KB
Volume
122
Category
Article
ISSN
0165-7992

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Frequency of sister chromatid exchanges
Frequency of sister chromatid exchanges in Bloom syndrome fibroblasts reduced by cocultivation with normal cells
✍ C. R. Bartram; H. W. RΓΌdiger; E. Passarge πŸ“‚ Article πŸ“… 1979 πŸ› Springer 🌐 English βš– 226 KB

Cocultivation of fibroblast cells from a male patient with Bloom syndrome (BS) and a female control reduced the rate of sister chromatid exchanges in the BS cells from a mean of 54 SCE per metaphase (range 42--65) to 41 (range 24--59). Medium used to culture control cells for 48 h also reduced the r