Effect of piperine on the inhibition of lung metastasis induced B16F-10 melanoma cells in mice
β Scribed by C.R. Pradeep; G. Kuttan
- Book ID
- 110408242
- Publisher
- Springer
- Year
- 2002
- Tongue
- English
- Weight
- 128 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0262-0898
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## Abstract B16F10 murine melanoma cell proliferation was inhibited after 48h in medium with serum in the range 0.1 to 0.5% by volume. Cell viability was mostly retained, whereas cells completely deprived of serum died. Growthβarrested cultures showed serumβdependent suppression of DNA synthesis. T
Systemic administration of swainsonine, an indolizidine alkaloid, inhibits the experimental metastasis of B 16-F10 murine melanoma cells. This activity can be attributed primarily to swainsonine-mediated enhancement of host natural killer cell activity. As one next step towards investigating the pot