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Effect of pH on red blood cell deformability

✍ Scribed by Drago Kuzman; Tadej Žnidarčič; Marjan Gros; Sonja Vrhovec; Saša Svetina; Boštjan Žekš

Publisher: Springer
Year: 2000
Tongue: English
Weight: 260 KB
Volume: 440
Category: Article
ISSN: 0031-6768
DOI: 10.1007/s004240000061

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## Abstract Hydroxyurea is a drug that is used to treat some patients with sickle cell disease. We have measured the deformability of sickle erythrocytes incubated in hydroxyurea in vitro and found that hydroxyurea acts to decrease the deformability of these cells. The deformability of normal eryth