𝔖 Bobbio Scriptorium
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Effect of pegylation on pharmaceuticals

✍ Scribed by Harris, J. Milton; Chess, Robert B.

Book ID
109949197
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
219 KB
Volume
2
Category
Article
ISSN
1474-1776

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Covalent attachment of poly(ethylene glycol) (PEG) to therapeutic antibody fragments has been found effective in prolonging the half-life of the protein molecule in vivo. In this study analytical ultracentrifugation (AUC) in combination with small angle X-ray scattering (SAXS) has been applied to a