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Effect of PEGylation on Biodistribution and Gene Silencing of siRNA/Lipid Nanoparticle Complexes

โœ Scribed by Yanjie Bao, Yi Jin, Padmanabh Chivukula, Jun Zhang, Yun Liu, Jian Liu, Jean-Pierre Clamme, Ram I. Mahato, Dominic Ng, Wenbin Ying, Yiting Wang, Lei Yu

Book ID
118808039
Publisher
Springer US
Year
2012
Tongue
English
Weight
539 KB
Volume
30
Category
Article
ISSN
0724-8741

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The influence of polymeric properties on
The influence of polymeric properties on chitosan/siRNA nanoparticle formulation and gene silencing
โœ Xiudong Liu; Kenneth A. Howard; Mingdong Dong; Morten ร˜. Andersen; Ulrik L. Rahb ๐Ÿ“‚ Article ๐Ÿ“… 2007 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 437 KB

We have previously introduced the use of the biomaterial chitosan to form chitosan/siRNA nanoparticles for gene silencing protocols. This present study shows that the physicochemical properties (size, zeta potential, morphology and complex stability) and in vitro gene silencing of chitosan/siRNA nan