𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo

✍ Scribed by Dr. Muthusamy Jayaraman; Dr. Steven M. Ansell; Dr. Barbara L. Mui; Dr. Ying K. Tam; Dr. Jianxin Chen; Dr. Xinyao Du; Dr. David Butler; Dr. Laxman Eltepu; Dr. Shigeo Matsuda; Dr. Jayaprakash K. Narayanannair; Dr. Kallanthottathil G. Rajeev; Dr. Ismail M. Hafez; Dr. Akin Akinc; Dr. Martin A. Maier; Dr. Mark A. Tracy; Dr. Pieter R. Cullis; Dr. Thomas D. Madden; Dr. Muthiah Manoharan; Dr. Michael J. Hope

Book ID
112001289
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
756 KB
Volume
51
Category
Article
ISSN
0044-8249

No coin nor oath required. For personal study only.

πŸ“œ SIMILAR VOLUMES

Development and validation of vectors co
Development and validation of vectors containing multiple siRNA expression cassettes for maximizing the efficiency of gene silencing
✍ Shunqing Wang; Zhenqi Shi; Wei Liu; Joel Jules; Xu Feng πŸ“‚ Article πŸ“… 2006 πŸ› BioMed Central 🌐 English βš– 949 KB

## Background RNA interference (RNAi) was originally identified as a biological process in which short double-stranded RNA (dsRNA) suppress the expression of genes complimentary to the dsRNA. This cellular intrinsic gene silencing mechanism has subsequently been developed as a useful tool for studi

Effect of siRNA nuclease stability on th
Effect of siRNA nuclease stability on the in vitro and in vivo kinetics of siRNA-mediated gene silencing
✍ Derek W. Bartlett; Mark E. Davis πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons 🌐 English βš– 306 KB πŸ‘ 2 views

## Abstract Small interfering RNA (siRNA) molecules achieve sequence‐specific gene silencing through the RNA interference (RNAi) mechanism. Here, live‐cell and live‐animal bioluminescent imaging (BLI) is used to directly compare luciferase knockdown by unmodified and nuclease‐stabilized siRNAs in r