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Effect of pCPA on nicotine-induced analgesia

✍ Scribed by Jo E. Cooley; Gregory A. Villarosa; Thomas W. Lombardo; Robert A. Moss; Stephen C. Fowler; Susan Sult


Book ID
113224027
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
236 KB
Volume
36
Category
Article
ISSN
0091-3057

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Tolerance to nicotine occurs in mice after its chronic administration. This tolerance is accompanied by an up-regulation of nicotinic receptors as assessed by the binding of (3H)-nicotine and alpha-(125I)-bungarotoxin (BTX). Past studies (Marks et al. 1983, 1986) have shown that the increase in BTX