Effect of particle size reduction on dissolution and oral absorption of a poorly water-soluble drug, cilostazol, in beagle dogs
β Scribed by Jun-ichi Jinno; Naoki Kamada; Masateru Miyake; Keigo Yamada; Tadashi Mukai; Masaaki Odomi; Hajime Toguchi; Gary G. Liversidge; Kazutaka Higaki; Toshikiro Kimura
- Book ID
- 113691134
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 201 KB
- Volume
- 111
- Category
- Article
- ISSN
- 0168-3659
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
The aim of the present work was to establish appropriate conditions for the dissolution/permeation system (D/P system) to estimate the effect of food intake on oral drug absorption. The D/P system is an in vitro assay system to evaluate the drug dissolution and permeation processes after oral admini
## Abstract The influence of dose volume on drug absorption following oral administration of a highly and a poorly water soluble drug was examined in male SpragueβDawley rats. A constant mass of each ^14^Cβlabeled compound was given via gavage in dose volumes of 1, 5, 10, and 20 mL kg^β1^. Blood le