Application of Dissolution/Permeation System for Evaluation of Formulation Effect on Oral Absorption of Poorly Water-Soluble Drugs in Drug Development
โ Scribed by Makoto Kataoka, Kiyohiko Sugano, Claudia da Costa Mathews, Jing Wen Wong, Kelly Lane Jones, Yoshie Masaoka, Shinji Sakuma, Shinji Yamashita
- Book ID
- 113077629
- Publisher
- Springer US
- Year
- 2011
- Tongue
- English
- Weight
- 398 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0724-8741
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๐ SIMILAR VOLUMES
The aim of the present work was to establish appropriate conditions for the dissolution/permeation system (D/P system) to estimate the effect of food intake on oral drug absorption. The D/P system is an in vitro assay system to evaluate the drug dissolution and permeation processes after oral admini
The solution of a poorly water-soluble drug in a liquid lipid-surfactant mixture, which served as a microemulsion preconcentrate, was converted into a solid form by incorporating it in a solid polyethylene glycol (PEG) matrix. The solid microemulsion preconcentrates thus formed consisted of Capmul P