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Effect of partial outlet obstruction of the rabbit urinary bladder on ryanodine binding to microsomal membranes

✍ Scribed by Robert M. Levin; Sheila S. Levin; Stephen A. Zderic; Masahiko Saito; Jai-Young Yoon; Alan J. Wein


Book ID
113328584
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
442 KB
Volume
25
Category
Article
ISSN
0306-3623

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Bladder outlet obstruction induces severe changes in urinary bladder function and metabolism. These changes are characterized by significant reductions in the ability of the in vitro whole bladder to generate pressure and to empty. Metabolically, partial outlet obstruction induces a shift from oxida

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Bladder function is dependent upon cellular metabolism of substrates and the adequate generation of high-energy phosphate compounds. Partial outlet obstruction induces a marked decrease in bladder function which is associated with a significant decrease in the oxidative metabolism of glucose. The cu

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## Abstract ## Aim To determine if tamsulosin treatment prevents or decreases the incidence and severity of outlet obstruction‐induced bladder dysfunction in rabbits. ## Materials and Methods Male New Zealand White rabbits were treated with tamsulosin or vehicle for 4 weeks with treatments initi