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Effect of ozone on drug-induced sleeping time in mice pretreated with mixed-function oxidase inducers and inhibitors

✍ Scribed by Judith A. Graham; Daniel B. Menzel; Frederick J. Miller; Joseph W. Illing; Donald E. Gardner

Book ID
113205858
Publisher
Elsevier Science
Year
1982
Tongue
English
Weight
788 KB
Volume
62
Category
Article
ISSN
0041-008X

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The biliary excretion of 3H-pentacaine and its metabolites was studied in rats pretreated with an inducer or inhibitor of mixed-function oxidases. Over one-fourth (25.8 per cent) of a 2 mg kg-' intraportal dose of 3H-pentacaine was excreted in bile in urethaneanaesthetized control rats within 3 h. T