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Effect of a mixed function oxidase inducer and inhibitor on monocrotaline pyrrole pneumotoxicity

✍ Scribed by Leon H. Bruner; Laurie J. Carpenter; Philip Hamlow; Robert A. Roth

Book ID
113206806
Publisher
Elsevier Science
Year
1986
Tongue
English
Weight
996 KB
Volume
85
Category
Article
ISSN
0041-008X

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The biliary excretion of 3H-pentacaine and its metabolites was studied in rats pretreated with an inducer or inhibitor of mixed-function oxidases. Over one-fourth (25.8 per cent) of a 2 mg kg-' intraportal dose of 3H-pentacaine was excreted in bile in urethaneanaesthetized control rats within 3 h. T