✦ LIBER ✦

Effect of osmotic gradient on the physical properties of membrane lipids in liposomes

✍ Scribed by Witold K. Surewicz

Publisher: Elsevier Science
Year: 1983
Tongue: English
Weight: 251 KB
Volume: 33
Category: Article
ISSN: 0009-3084
DOI: 10.1016/0009-3084(83)90010-5

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✦ Synopsis

Osmotic swelling of multilamellar liposomes was shown to produce structural changes in liposomal membranes. Creation of transmembrane osmotic gradients results in an increased lateral mobility of membrane incorporated hydrophobic probe, pyrene. This is accompanied by some decrease in order parameter of membrane phospholipid polar head group regions. The perturbations are more marked in hydrophobic than in polar regions of the membranes. It is suggested that some functional changes in biomembranes arising upon osmotic swelling may be associated with structural alterations similar to those observed in liposomes.

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