Effect of non-linear plasma protein binding on unbound and total plasma phenylbutazone concentrations in cows
β Scribed by F. D. BOUDINOT; R.J. WILLIAMS; J. A. SMITH
- Book ID
- 114744633
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- English
- Weight
- 316 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0140-7783
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π SIMILAR VOLUMES
The response of steady-state distribution volume (V,, for total and Vdssu for unbound drug) of valproate (VPA) to dose-dependent plasma protein binding was studied in guinea-pigs. Various steady-state plasma concentrations of VPA were achieved by intravenous constant infusion. The concentrations of
The aim of this work was to provide a short overview of existing methods for the determination of free drug concentration and protein-drug binding fraction in plasma. Various methods have been described in terms of principles, evaluation of methods, and applications in recent years, with an emphasis