Effect of nifedipine and anticonvulsants of kainic acid-induced seizures in mice
β Scribed by Dale E. Braun; William J. Freed
- Book ID
- 115801319
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- English
- Weight
- 340 KB
- Volume
- 533
- Category
- Article
- ISSN
- 0006-8993
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## Abstract Kainic acid (KA)βinduced status epilepticus (SE) is a wellβcharacterized model of excitotoxic neuronal injury. Excitotoxicity results from activation of specific glutamate receptors, with resultant elevation of intracellular Ca^2+^. The CA1 and CA3 subregions of the hippocampus are espe
The K+ channel blocker 4-aminopyridine (4-AP) causes epileptiform activity in in vitro preparations and is a potent convulsant in animals and man. In mice, 4-AP produces behavioral activation, clonic limb movements and wild running, followed by tonic hindlimb extension and death (ED97, 13.3 mg/kg, s