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Effect of nicotinamide on RNA and DNA synthesis and on poly(ADP-ribose) polymerase activity in normal and phytohemagglutinin stimulated human lymphocytes

✍ Scribed by C. Rochette-Egly; M.E. Ittel; J. Bilen; P. Mandel


Book ID
115911476
Publisher
Elsevier Science
Year
1980
Tongue
English
Weight
435 KB
Volume
120
Category
Article
ISSN
0014-5793

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## Abstract The effect of nicotinamide on unscheduled DNA synthesis was studied in resting human lymphocytes. In cells treated with UV irradiation or with MNNG, nicotinamide caused a two‐fold stimulation of unscheduled DNA synthesis and retarded the rate of NAD^+^ lowering caused by these treatment

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