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Effect of neostigmine on the tissue concentration of antibiotic in streptomycin treated rats

✍ Scribed by Vernon A. Green

Publisher: John Wiley and Sons
Year: 1963
Tongue: English
Weight: 308 KB
Volume: 52
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.2600520307

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✦ Synopsis

Increased streptomycin levels in rat skeletal muscle tissue were observed after the administration of neostigmine methylsulfate alone and in combination with atropine. Acetylcholine and methacholine bromide were administered to determine if the increase in antibiotic concentration was due to vasodilation or to some other action of the anticholinesterase.

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