Effect of etodolac on the prostaglandin concentrations in the kidney of the normal rat

✍ Scribed by Dr. David K.H. Lee

• Publisher: John Wiley and Sons
• Year: 1986
• Tongue: English
• Weight: 440 KB
• Volume: 9
• Category: Article
• ISSN: 0272-4391
• DOI: 10.1002/ddr.430090408

✦ Synopsis

Lee, D.K.H.: Effect of etodolac on the prostaglandin concentrations in the kidney of the normal rat. Drug Dev. Res. 9:305-311, 1986.

The effect of acute and subchronic dosing with etodolac on the renal PGE2 and 6-keto-PGF,, concentrations in the normal rat were studied. Etodolac and other nonsteroidal antiinflammatory drugs (NSAIDs) were administered orally, at equieffective antiinflammatory doses, to normal rats either as a single dose or as seven daily doses. Whole kidney prostaglandin (PG) concentrations were measured. In the acute study, etodolac (3 mg/kg) did not significantly lower the PGE2 levels for up to 4 hr postdosing. In contrast, naproxen (3 mg/kg) and piroxicam (0.5 mg/kg) significantly decreased the PGE2 levels to about 20% and 60% of control, respectively. Similar reductions in 6-keto-PGF1, concentrations were observed. In the subchronic study, etodolac (3 mglkglday) did not lower either PGE2 or 6-keto-PGF1, concentrations whereas naproxen (3 mg/kg/day), piroxicam (0.5 mg/kg/day), indomethacin (1 mg/kg/day), and aspirin (300 mg/kg/day) significantly decreased both PGs. In both studies, the effect of etodolac was significantly different from that of the NSAIDs. It is concluded that etodolac possesses only a very weak capacity to lower renal PGs, and therefore is unlikely to cause any renal complications related to PG biosynthesis inhibition.