Effect of neonatal 6-hydroxydopamine treatment on audiogenic seizures
β Scribed by William M. Bourn; Lincoln Chin; Albert L. Picchioni
- Book ID
- 118937727
- Publisher
- Elsevier Science
- Year
- 1977
- Tongue
- English
- Weight
- 235 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0024-3205
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Convulsions from combined pinealectomy and parathyroidectomy were examined in rats treated as neonates with 6-hydroxydopamine (6-OHDA). Injection of 6-OHDA caused a significant reduction in the average latency to onset of clonictonic convulsions. Moreover, of the 6-OHDA-treated rats which convulsed,
The ontogenetic development of the audiogenic immobility reaction (freezing) was studied in rats given intracisternal injections of the neurotoxins 5,7-dihydroxytryptamine (5,7-DHT), 25 gg, or 6-hydroxydopamine (6-OHDA), 100 gg, neonatally (Day 1). The duration of the freezing response was strongly