Alteration of seizures resulting from pinealectomy in the rat after neonatal treatment with 6-hydroxydopamine
✍ Scribed by C. A. Stockmeier; B. R. Larsen; D. E. Blask
- Publisher
- John Wiley and Sons
- Year
- 1985
- Tongue
- English
- Weight
- 377 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0360-4012
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✦ Synopsis
Convulsions from combined pinealectomy and parathyroidectomy were examined in rats treated as neonates with 6-hydroxydopamine (6-OHDA). Injection of 6-OHDA caused a significant reduction in the average latency to onset of clonictonic convulsions. Moreover, of the 6-OHDA-treated rats which convulsed, nearly half of them died during a seizure. In sham-pinealectomized rats. neonatal treatment with 6-OHDA reduced norepinephrine (NE) and increased dopamine levels in the forebrain while brainstem levels of NE were increased. Pretreatment with desmethylimipramine reversed the effects of 6-OHDA on convulsions and catecholamine levels. The results indicate that catecholamine lesions with 6-OHDA exacerbate convulsions from pinealectomy .