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Effect of neoadjuvant chemotherapy for lymph node micrometastasis and tumor cell microinvolvement in the patients with esophageal carcinoma

✍ Scribed by Shoji Natsugoe; Masataka Matsumoto; Saburo Nakashima; Hiroshi Okumura; Futoshi Miyazono; Fumio Kijima; Sumiya Ishigami; Kuniaki Aridome; Chikara Kusano; Masamichi Baba; Sonshin Takao; Takashi Aikou

Book ID
117466605
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
838 KB
Volume
159
Category
Article
ISSN
0304-3835

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## BACKGROUND. In a previous study the authors demonstrated, using immunohistochemical methods for epithelial antigens, that the regional lymph nodes of gastric adenocarcinoma contained individual tumor cells or small clusters of these cells (tumor cell microinvolvement [TCM]) in over 90% of cases

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W e recently read the article by Glickman et al. regarding the prognostic significance of lymph node micrometastasis in esophageal carcinoma patients. 1 Indeed, it addresses a very interesting topic, and we would like to make a few observations. First, as stated in the article, the surgical procedur

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## BACKGROUND. Tumor involvement of regional lymph nodes has a crucial impact on the prognosis of patients with adenocarcinoma of the esophagogastric junction (AEG). Although additional tumor cell deposits can be detected by sensitive methods (e.g., immunohistochemistry and polymerase chain reacti