✦ LIBER ✦

Effect of natural human interferon-beta on the replication of human cytomegalovirus

✍ Scribed by Kazuo Nakamura; Dr. Yoshito Eizuru; Yoichi Minamishima

Publisher: John Wiley and Sons
Year: 1988
Tongue: English
Weight: 665 KB
Volume: 26
Category: Article
ISSN: 0146-6615
DOI: 10.1002/jmv.1890260404

No coin nor oath required. For personal study only.

✦ Synopsis

The antiviral effect of natural human interferon-beta (HuIFN-0) against human cytomegalovirus (CMV) was evaluated in human embryonic lung fibroblasts (HEL). Natural HuIFN-0, like other HuIFNs, inhibited the replication of CMV. Pretreatment of the cells with natural HuIFN-P inhibited the appearance of immediate-early antigen (IEA) or pre-early nuclear antigen (PENA) as well as the production of infectious CMV. After a single treatment with natural HuIFN-0, intracellular 2', 5'-oligoadenylate (2-5A) synthetase activity was induced and maintained at a high level for several days. The anti-CMV effect of natural HuIFN-0 correlated with the intracellular 2-5A synthetase activity.

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