Effect of Multinuclear Copper/Aluminum Complexes in Highly Asymmetric Conjugate Addition of Trimethylaluminum to Acyclic Enones
β Scribed by Endo, Kohei; Hamada, Daisuke; Yakeishi, Sayuri; Shibata, Takanori
- Book ID
- 118751660
- Publisher
- John Wiley and Sons
- Year
- 2012
- Tongue
- English
- Weight
- 394 KB
- Volume
- 125
- Category
- Article
- ISSN
- 0044-8249
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π SIMILAR VOLUMES
In the typical procedure in the Experimental Section of this paper (see also the Supporting Information), the first sentence should read: "The aryl iodide (1.05 mmol) was dissolved in Et 2 O (0.5 mL) under an inert atmosphere and cooled to Γ55 8C before the addition of nBuLi (1.05 mmol, 656 mL, 1.6
Scheme 1. Transmetalation of phenylboronic acid to triethylaluminum. CuTC = copper thiophencarboxylate. Scheme 2. I/Li-exchange-Li/Al-transmetalation sequence.
Four phosphites obtained by linking enantiomerically pure binaphthylchlorophosphite to the two different hydroxy groups of deoxycholic acid were synthesized and used as chiral ligands in the enantioselective copper-catalyzed 1,4-addition of diethylzinc to acyclic enones. The ligands were screened fo