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Effect of Moisture on the Stability of a Lyophilized Humanized Monoclonal Antibody Formulation

โœ Scribed by E. D. Breen; J. G. Curley; D. E. Overcashier; C. C. Hsu; S. J. Shire


Book ID
110318557
Publisher
Springer US
Year
2001
Tongue
English
Weight
314 KB
Volume
18
Category
Article
ISSN
0724-8741

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## Purpose: To investigate the effect of plasticizers on the stability of protein formulations in the solid state and to apply these results to a study of mechanisms of protein stabilization by sugars in the solid sate. ## Methods: The igg1 antibody was formulated with either sucrose or trehalose