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Effect of manoalide on human 5-lipoxygenase activity

✍ Scribed by F. Cabré; A. Carabaza; N. Suesa; A. M. García; E. Rotllan; M. Gómez; D. Tost; D. Mauleón; G. Carganico

Publisher
SP Birkhäuser Verlag Basel
Year
1996
Tongue
English
Weight
650 KB
Volume
45
Category
Article
ISSN
1420-908X

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✍ Pat Wheelan; Robert C. Murphy 📂 Article 📅 1997 🏛 Elsevier Science 🌐 English ⚖ 132 KB

A reverse-phase-HPLC/tandem mass spectrometric method (LC/MS/MS) was developed for the quantitation of leukotriene B4 (LTB4), the 5-lipoxygenase product, 5-hydroxyeicosatetraenoic acid (5-HETE), as well as the omega-oxidation metabolites of LTB4, 20-hydroxy-LTB4, and 20-carboxy-LTB4. Electrospray-ge