Effect of magnesium deficiency on fatty acid composition of the erythrocyte membrane and plasma lipid concentration in rats

✍ Scribed by A. Lerma; E. Planells; P. Aranda; J. Llopis

• Publisher: Elsevier Science
• Year: 1995
• Tongue: English
• Weight: 703 KB
• Volume: 6
• Category: Article
• ISSN: 0955-2863
• DOI: 10.1016/0955-2863(95)00128-m

✦ Synopsis

We studied the effects of a magnesium (~g)-deficient diet fed to rats (255 mgikg of feed) on plasma lipid concentrations on days 7, 35, 42, 56, 63, and 70 and analyzed the changes in fatty acid composition of the erythrocyte membrane on day 75. Dietary Mg deficiency signtjkantly increased free cholesterol, triglyceride, and phospholipid concentrations from day 7 of treatment and led to signtficant increases in total cholesterol from day 35 of treatment until the end of the experimental period. On day 70, Mg deficiency had reduced oleic acid (OA} (18:In9) and ara&hidoni~ acid (AA) ~20:4n~} in the e~thro~te me~rane, and had increased eicosatrienoic (25:3n6), docosapentaenoic (22:5n6), and eicosapentaenoic acid (20:5n3). Our findings suggest that the decrease in AA after long-term (70 days) dietary Mg deficiency was not due to decreased A-Gdesaturase activity, in contrast with earlier studies. (