Effect of Macromolecular Crowding on Reaction Rates: A Computational and Theoretical Study
โ Scribed by Kim, Jun Soo; Yethiraj, Arun
- Book ID
- 119204493
- Publisher
- Biophysical Society
- Year
- 2009
- Tongue
- English
- Weight
- 554 KB
- Volume
- 96
- Category
- Article
- ISSN
- 0006-3495
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๐ SIMILAR VOLUMES
## Abstract In cells, proteins execute specific tasks in crowded environments; these environments influence their stability and dynamics. Similarly, for an enzyme molecule encapsulated in an inorganic cavity as in biosensors or biocatalysts, confinement or excluded volume plays an important role in
## Abstract Macromolecular crowding is expected to have several significant effects on protein aggregation; the major effects will be those due to excluded volume and increased viscosity. In this report we summarize data demonstrating that macromolecular crowding may lead to a dramatic acceleration
Inside the living cell is inherently crowded with proteins and other macromolecules. Thus, it is indispensable to take into account various interactions between the protein and other macromolecules for thorough understanding of protein functions in cellular contexts. Here we focus on the excluded vo