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Effects of macromolecular crowding on protein folding and aggregation studied by density functional theory: Dynamics

โœ Scribed by Kinjo, Akira; Takada, Shoji

Book ID
111967340
Publisher
The American Physical Society
Year
2002
Tongue
English
Weight
293 KB
Volume
66
Category
Article
ISSN
1063-651X

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Inside the living cell is inherently crowded with proteins and other macromolecules. Thus, it is indispensable to take into account various interactions between the protein and other macromolecules for thorough understanding of protein functions in cellular contexts. Here we focus on the excluded vo

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## Abstract In cells, proteins execute specific tasks in crowded environments; these environments influence their stability and dynamics. Similarly, for an enzyme molecule encapsulated in an inorganic cavity as in biosensors or biocatalysts, confinement or excluded volume plays an important role in