Effect of Macromolecular Crowding on Protein Folding Dynamics at the Secondary Structure Level
โ Scribed by Smita Mukherjee; Matthias M. Waegele; Pramit Chowdhury; Lin Guo; Feng Gai
- Book ID
- 116664241
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 581 KB
- Volume
- 393
- Category
- Article
- ISSN
- 0022-2836
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Inside the living cell is inherently crowded with proteins and other macromolecules. Thus, it is indispensable to take into account various interactions between the protein and other macromolecules for thorough understanding of protein functions in cellular contexts. Here we focus on the excluded vo
## Abstract In cells, proteins execute specific tasks in crowded environments; these environments influence their stability and dynamics. Similarly, for an enzyme molecule encapsulated in an inorganic cavity as in biosensors or biocatalysts, confinement or excluded volume plays an important role in