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Effect of LY 171555 and CY 208-243 on tremor suppression in the MPTP monkey model of parkinsonism

✍ Scribed by Baltazar Gomez-Mancilla; René Boucher; Dr. Paul J. Bédard

Publisher: John Wiley and Sons
Year: 1992
Tongue: English
Weight: 493 KB
Volume: 7
Category: Article
ISSN: 0885-3185
DOI: 10.1002/mds.870070108

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✦ Synopsis

Abstract

The antitremor effect of the D~2~ agonist LY 171555 and of the D~1~ agonist CY 208‐243 alone and in combination was tested in a monkey previously rendered parkinsonian by MPTP and displaying exceptionally a rest termor in the limbs. The D~2~ agonist suppressed rest tremor in a dose‐dependent fashion. The D~1~ agonist by itself had no effect but it potentiated the effect of a small dose of LY 171555.

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