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Effect of ethosuximide on rest tremor in the MPTP monkey model

✍ Scribed by Baltazar Gomez-Mancilla; Jean-François Latulippe; René Boucher; Dr. Paul J. Bédard

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
459 KB
Volume
7
Category
Article
ISSN
0885-3185

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✦ Synopsis

Abstract

Based on the hypothesis that low‐threshold calcium conductance in the thalamus might be involved in the pathophysiology of parkinsonian tremor, ethosuximide was given chronically to a monkey previously treated with MPTP and displaying exceptionally a typical rest tremor. After 5 days of daily treatment, the tremor was reduced by 60%. Diltiazem and verapamil which act on different calcium channels had no such effect. Ethosuximide also potentiated the antitremor effect of the dopamine D~2~ agonist LY‐171555.

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