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Effect of low-dose omeprazole on gastric acid secretion in duodenal ulcer patients

✍ Scribed by G. McLAUCHLAN; G. P. CREAN; K. E. L. McCOLL


Book ID
108602802
Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
258 KB
Volume
2
Category
Article
ISSN
0269-2813

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Omeprazole in elderly duodenal ulcer pat
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The effect of omeprazole on acid secretion and gastrin levels has been investigated in 10 elderly duodenal ulcer patients in remission. Doses of 5, 10, 20 and 40 mg omeprazole were given once daily for 7 consecutive days and the basal (BAO) and peak (PAO) acid output and fasting plasma gastrin conce

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## Summary A proximal gastric vagotomy (PGV) prevented experimental duodenal ulcers in rats for only 5 days and thereafter all rats developed duodenal ulceration. In sham-operated rats the mean stimulated gastric acid output was 186 ΞΌmol/60 min. Immediately following a PGV there was a significant d