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Effect of long-term co-administration of Wuzhi tablet (Schisandra sphenanthera extract) and prednisone on the pharmacokinetics of tacrolimus

✍ Scribed by Qin, Xiao-Ling; Yu, Tao; Li, Ling-Jue; Wang, Ying; Gu, Hao-Min; Wang, Yong-Tao; Huang, Min; Bi, Hui-Chang


Book ID
121301380
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
636 KB
Volume
20
Category
Article
ISSN
0944-7113

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Study of the effect of Wuzhi tablet (Sch
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## Abstract A liquid chromatography/tandem mass spectrometry (LC‐MS/MS) method was developed and validated for determining tacrolimus (FK506) in rat tissues to study the effect of __Schisandra sphenanthera__ extract on FK506 tissue distribution. After a liquid–liquid extraction with ethyl acetate,