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Effects of Schisandra sphenanthera extract on the pharmacokinetics of tacrolimus in healthy volunteers

✍ Scribed by Hua-Wen Xin; Xiao-Chun Wu; Qing Li; Ai-Rong Yu; Min Zhu; Yang Shen; Dan Su; Lei Xiong

Book ID
108641868
Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
149 KB
Volume
64
Category
Article
ISSN
0306-5251

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## Abstract A liquid chromatography/tandem mass spectrometry (LC‐MS/MS) method was developed and validated for determining tacrolimus (FK506) in rat tissues to study the effect of __Schisandra sphenanthera__ extract on FK506 tissue distribution. After a liquid–liquid extraction with ethyl acetate,