Effect of liquid volume and food intake on the absolute bioavailability of danazol, a poorly soluble drug
✍ Scribed by Vibeke Hougaard Sunesen; Rune Vedelsdal; Henning Gjelstrup Kristensen; Lona Christrup; Anette Müllertz
- Book ID
- 113591429
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 162 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0928-0987
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📜 SIMILAR VOLUMES
The aim of the present work was to establish appropriate conditions for the dissolution/permeation system (D/P system) to estimate the effect of food intake on oral drug absorption. The D/P system is an in vitro assay system to evaluate the drug dissolution and permeation processes after oral admini
## Abstract The influence of dose volume on drug absorption following oral administration of a highly and a poorly water soluble drug was examined in male Sprague‐Dawley rats. A constant mass of each ^14^C‐labeled compound was given via gavage in dose volumes of 1, 5, 10, and 20 mL kg^−1^. Blood le