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Effect of ketoprofen and indomethacin on methotrexate pharmacokinetics in mice plasma and tumor tissues

✍ Scribed by Yasmine M. Elmorsi, Sahar M. El-Haggar…

Book ID
120721243
Publisher
Springer-Verlag
Year
2012
Tongue
English
Weight
256 KB
Volume
38
Category
Article
ISSN
0378-7966

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Effect of indomethacin on the pharmacoki
Effect of indomethacin on the pharmacokinetics of methotrexate in rabbits
✍ Tawfeeg A. O. Najjar; Abdel Rehim M. Morad; Rao Muzaffar A. Khan 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 300 KB 👁 3 views

## Abstract The interaction between indomethacin (IND) and methotrexate (MTX) was investigated in rabbits. The study was designed so as to evaluate the effect of IND (1 mg h^−1^) during a continuous MTX infusion (1·2 mg kg^−1^) over 240 min. IND was injected i.v. at hourly intervals after a steady