Effect of ion modification of commonly used orthopedic materials on the attachment of human bone-derived cells

✍ Scribed by Howlett, C. Rolfe ;Zreiqat, Hala ;Wu, Yan ;McFall, David W. ;McKenzie, David R.

• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 310 KB
• Volume: 45
• Category: Article
• ISSN: 0021-9304
• DOI: 10.1002/(sici)1097-4636(19990615)45:4<345::aid-jbm9>3.0.co;2-j

✦ Synopsis

Biomaterials which combine optimum properties of strength and biocompatibility are desirable in improving the long-term performance of implantable medical devices. Our study is aimed at developing technology designed to alter the outer atomic layers of a material to give the desired compatibility with the tissue while retaining the properties of the bulk substratum. Materials used in this study were titanium vanadium alloy (Ti-6Al-4V) and cobalt chromium molybdenum alloy (Co-Cr). Soda lime glass discs and polyethylene terephthalate (PET) acted as controls. A cathode of either Ti-6Al-4V or Co-Cr was used to simultaneously deposit and implant identified substrata. The attachment of human bone-derived cells (HBDC) to various materials was determined using radiolabeling or colorimetric assays. Results show that HBDC adhere preferentially to the unmodified surfaces of Ti-6Al-4V and Ti-6Al-4V on glass compared to the unmodified Co-Cr surfaces and to that of the Co-Cr on glass. Depositing Ti-6Al-4V on Co-Cr gives significantly better attachment of HBDC than when depositing Co-Cr onto Ti-6Al-4V. While cellular attachment to the created surfaces reflects that of the cathodic materials, it is not identical to these materials. Ion deposition/implantation is capable of creating permanent surfaces which reflect the adhesion of source materials not bulk substrata.