𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Effect of induction chemotherapy on speech and swallowing function in patients with oral tongue cancer

✍ Scribed by Denise A. Barringer; Katherine A. Hutcheson; Erich M. Sturgis; Merrill S. Kies; Jan S. Lewin

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
196 KB
Volume
31
Category
Article
ISSN
1043-3074

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Background.

Swallowing physiology, diet, and patient‐reported outcomes were evaluated after induction chemotherapy for oral tongue cancer.

Methods.

Fifteen of 23 patients enrolled in a phase II clinical trial of induction chemotherapy followed by surgical resection for oral tongue cancer underwent instrumental and perceptual analysis of speech and swallowing. Oropharyngeal swallow efficiency (OPSE) was calculated. Patient‐reported outcomes were collected. We compared pre‐ and postchemotherapy results.

Results.

OPSE scores were not significantly different (p > .05) after induction chemotherapy; however, patient‐reported swallowing and diet levels were significantly higher (p < .001 and p = .015, respectively). Diet levels improved from soft‐chewable to full diet in most patients. Speech intelligibility did not change (p = .328).

Conclusion.

It appears that induction chemotherapy has a negligible effect on speech and swallowing physiology but may provide symptomatic improvement of pain and swallowing after treatment. Further investigations are needed to corroborate these findings. © 2008 Wiley Periodicals, Inc. Head Neck, 2009

📜 SIMILAR VOLUMES

Effects of radiotherapy with or without
Effects of radiotherapy with or without chemotherapy on tongue strength and swallowing in patients with oral cancer
✍ Cathy Lazarus; Jeri A. Logemann; Barbara Roa Pauloski; Alfred W. Rademaker; Iren 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 118 KB

## Abstract ## Background. Oral tongue strength and swallowing ability are reduced in patients treated with chemoradiotherapy for oral and oropharyngeal cancer. ## Methods. Patients with oral or oropharyngeal cancer treated with high‐dose chemoradiotherapy underwent tongue strength, swallowing,

Relationship between swallow motility di
Relationship between swallow motility disorders on videofluorography and oral intake in patients treated for head and neck cancer with radiotherapy with or without chemotherapy
✍ Barbara Roa Pauloski; Alfred W. Rademaker; Jerilyn A. Logemann; Lisa Newman; Ell 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 157 KB 👁 1 views

## Background: Current research demonstrates that swallow function is impaired after treatment with organ-sparing chemoradiotherapy. few studies, however, have related observed swallowing disorders with the patient's oral intake and diet in a large cohort of patients. ## Methods: Swallowing funct

Patient-reported measurements of oral mu
Patient-reported measurements of oral mucositis in head and neck cancer patients treated with radiotherapy with or without chemotherapy : Demonstration of increased frequency, severity, resistance to palliation, and impact on quality of life
✍ Linda S. Elting; Dorothy M. Keefe; Stephen T. Sonis; Adam S. Garden; F. K. L. Sp 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 358 KB 👁 2 views

## Abstract ## BACKGROUND. The risk, severity, and patient‐reported outcomes of radiation‐induced mucositis among head and neck cancer patients were prospectively estimated. ## METHODS. A validated, patient‐reported questionnaire (OMDQ), the FACT quality of life (QOL), and the Functional Assessm

Acute effects of the oral administration
Acute effects of the oral administration of midodrine, an α-adrenergic agonist, on renal hemodynamics and renal function in cirrhotic patients with ascites
✍ Paolo Angeli; Roberta Volpin; Donatella Piovan; Andrea Bortoluzzi; Raffaella Cra 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 86 KB 👁 1 views

The effects of the acute administration of arterial vasoconstrictors on renal plasma flow (RPF) and urinary sodium excretion (UNaV) in cirrhotic patients with ascites with or without hepatorenal syndrome (HRS) are still controversial. As a consequence, vasoconstrictors are not actually used in the t