Effect of indomethacin suppositories on rectal polyposis in patients with familial adenomatous polyposis

✍ Scribed by Chiharu Hirota; Mitsuo Iida; Kunihiko Aoyagi; Takayuki Matsumoto; Shuji Tada; Takashi Yao; Masatoshi Fujishima

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 533 KB
• Volume: 78
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/(sici)1097-0142(19961015)78:8<1660::aid-cncr4>3.0.co;2-i

✦ Synopsis

BACKGROUND.

Oral sulindac is known to reduce polyps in patients with familial adenomatous polyposis (FAP). The authors speculated that rectal administration of indomethacin would he effective therapy for adenomas in the rectal remnant of FAP. METHODS. Eight patients with FAP who had been treated by total colectomy with ileorectal anastomosis were administered an indomethacin suppository (50 mg) once or twice daily during a period of 4 or 8 weeks. The number of polyps at the same site within the rectum was counted under proctoscopy prior to, at the end of, and after the treatment. In four patients, proliferative activity of the rectal mucosa was assessed by immunohistochemical staining for MIB-1.