A catalytic asymmetric conjugate addition reaction of organocopper reagents, generated from copper salt, a chiral phosphine, and Grignard reagent, with cyclohexenone is highly dependent on the counter anion of copper species, solvents, Grignard reagents, and the structure of the chiral phosphine. Th
Effect of InCl3 on the addition of Grignard reagents to α,β-unsaturated carbonyl compounds
✍ Scribed by Brian G. Kelly; Declan G. Gilheany
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- French
- Weight
- 94 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
The enantioselective copper-catalyzed 1,4-addition of Grignard reagents to a$-unsaturated carbonyl compounds was studied with the following Cu' compounds as catalyst precursor and 1,2 : 5,6-di-0 -isopropylidene-3thio-a -o-glucofuranose (Hsiig) as chiral ligand: CuI, iodo[bis(dibutylsulfide)]copper(I
Catalytic Enantioselective Conjugate Addition of Grignard Reagents to Cyclic α,β-Unsaturated Carbonyl Compounds. -The outcome of the title reaction is influenced by many factors such as amount and structure of the chiral phosphine, copper salt, Grignard reagent, as well as the solvent used.