Effect of ibuprofen dosage on patient response in rheumatoid arthritis

✍ Scribed by Robert G. Godfrey; Susano De La Cruz

• Publisher: John Wiley and Sons
• Year: 1975
• Tongue: English
• Weight: 260 KB
• Volume: 18
• Category: Article
• ISSN: 0004-3591
• DOI: 10.1002/art.1780180209

✦ Synopsis

Abstract

In a 4‐week double‐blind trial in 41 patients with rheumatoid arthritis, ibuprofen (Motrin®) decreased the swollen joint count significantly at a dosage level of 2400 mg/day, but not at 1200 mg/day. Ibuprofen probably does have antiinflammatory effects in man, but only at higher dosages; antiarthritic activity at lower dosages reflects primarily analgesia and perhaps antipyretic effects. Complaints and clinical laboratory findings did not differ significantly between the dosage groups.