Although the depletion of hepatic glutathione in male rats following treatment with phorone (diisopropylidene acetone) did not affect the xenobiotic-metabolizing microsomal enzyme system, the metabolic elimination of vinylidene chloride (VDC) from the atmosphere of a closed exposure system was inhib
Effect of Hypoxia on the Metabolism and Hepatotoxicity of Carbon Tetrachloride and Vinylidene Chloride in Rats
β Scribed by Siegers, Claus-Peter ;Horn, Werner ;Younes, Maged
- Book ID
- 114800493
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 2009
- Weight
- 369 KB
- Volume
- 56
- Category
- Article
- ISSN
- 0001-6683
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## Abstract Hepatotoxicity of vinylidene chloride (1,1βdichloroethylene, VDC) in rats was evidenced by increases of serum enzyme activities of the aminotransferases (GOT, GPT) and sorbitol dehydrogenase (SDH). Simultaneous treatment with ethanol (4.8 g kg^β1^ p.o.) totally inhibited these hepatotox
The preventive effect of neutropenia on carbon tetrachloride (CCl4)-induced hepatotoxicity was examined in rats. In rats treated once with CCl4 (1 ml kg(-1), i.p.), the serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), indices of liver cell damage, and the hepatic