Irinotecan (CPT-11) is a semisynthetic derivative of camptothecine that has proved activity in the treatment of colorectal carcinoma. The metabolites identiยฎed in humans include SN-38, SN-38 glucuronide, and several CYP3A-derived metabolites. We have studied the hepatic extraction, metabolism, and b
Effect of hypoxia on the hepatic metabolism of lidocaine in the isolated perfused pig liver
โ Scribed by Dr. Berend Mets; Rosemary Hickman; Rosemary Allin; Jean van Dyk; Zoe Lotz
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 890 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0270-9139
No coin nor oath required. For personal study only.
โฆ Synopsis
Lidocaine metabolism appears to be significantly impaired by liver dysfunction of varying pathogeneses (1,2). The responsible mechanisms are subject to debate
๐ SIMILAR VOLUMES
The effects of acetaminophen on the metabolism of the isolated perfused rat liver were investigated. The following results were obtained: (1) Acetaminophen increased glucose release and glycolysis from endogenous glycogen (glycogenolysis). (2) Oxygen uptake, gluconeogenesis from either pyruvate or
We studied the effects of a series of vasodilators on intrahepatic vascular resistance of isolated perfused cirrhotic rat livers in basal conditions and during norepinephrine-induced vasoconstriction. Cirrhosis was induced by repeated intraperitoneal injections of carbon tetrachloride. The vasodilat
## Abstract The effects of zymosan on transport, distribution, and metabolism of octanoate in the perfused rat liver were investigated using the multipleโindicator dilution technique. Livers were perfused with 300 ยตM octanoate in the absence or in the presence of 100 ยตg/mL zymosan. Tracer amounts o