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Effect of hypoxia on the binding and subcellular distribution of iron regulatory proteins

✍ Scribed by Tania Christova; Douglas M. Templeton


Book ID
106458169
Publisher
Springer
Year
2007
Tongue
English
Weight
438 KB
Volume
301
Category
Article
ISSN
0300-8177

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Iron is essential for many biological processes, including oxygen delivery, and its supply is tightly regulated. Iron regulatory proteins (IRPs, IRP1 and IRP2) are master regulators of cellular iron metabolism. Hypoxia triggers a broad range of gene responses that are primarily mediated by hypoxia-i