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Effect of hyperoxia-induced oxidative stress on the cytotoxicity and mutagenicity of UV and EMS in Chinese hamster ovary cells

✍ Scribed by J.J.P. Gille; C.G.M. van Berkel; M.J. de Riemer; C.C. van de Kerkhof; H. Joenje

Book ID
113252522
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
86 KB
Volume
271
Category
Article
ISSN
0165-1161

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The possible mechanism for heat protection by the protein synthesis inhibitor histidinol was investigated in CHO cells. Histidinol (HST, 5 mM), an analogue of the essential amino acid L-histidine, added for 2 hr before and during heating at 43"C, protected cells from killing at 43Β°C. Treatment with